BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN TZID:Europe/Paris X-WR-TIMEZONE:Europe/Paris BEGIN:VEVENT UID:1217@i2m.univ-amu.fr DTSTART;TZID=Europe/Paris:20160511T110000 DTEND;TZID=Europe/Paris:20160511T120000 DTSTAMP:20160426T090000Z URL:https://www.i2m.univ-amu.fr/evenements/alternative-transcriptions-and- translations-expand-the-human-mitogenomic-proteome/ SUMMARY: (...): Alternative transcriptions and translations expand the huma n mitogenomic proteome DESCRIPTION:: Nucleotide sequences\, such as rRNA genes\, are multi-tasked\ , beyond 'known' function\, i.e. coding for the protein ribin [1]. Regular protein coding genes might actually code for several widely different pro teins due to:(a) translational activity by stop-suppressor tRNAs [2\,3](b) tRNAs with expanded codons [4\,5](c) Systematic transcriptional transform ations alter coding and other properties of RNAs\, such as systematic dele tions after each trinucleotide\, or systematic nucleotide exchanges (e. g. AG) over complete genes [6\,7].Human mitochondrial RNAs sequenced by cl assical and next generation methods match various transformations.Peptides matching specifically detected transformed RNAs occur in human mass spect rometry mitoproteomic data [8\,9]\, have also been detected by monoclonal antibodies [10].Alternative transcriptions and translations explain trashe d -omic data\, increasing considerably coding potential.1. Barthélémy RM \, Grino M\, Casanova J-P\, Faure E 2010 Ribin-like proteins expression in the chaetognath Spadella cephaloptera. Int J Genet Mol Biol 2\, 20–29.2 . Capone JP\, Sharp PA\, RajBhandary UL 1985 Amber\, ochre and opal suppre ssor tRNA genes derived from a human serine tRNA gene. Embo J 4\, 213-221. 3. Seligmann H 2010 Avoidance of antisense antiterminator tRNA anticodons in vertebrate mitochondria. Biosystems 101\, 42-50.4. Riddle DL\, Roth JR 1972 Frameshift suppressors. 3. Effects of suppressor mutations on transfe r RNA. J Mol Biol 66\, 495-506.5. Seligmann H 2012 Putative mitochondrial polypeptides coded by expanded quadruplet codons\, decoded by antisense tR NAs with unusual anticodons. Biosystems 110\, 84-106.6. Seligmann H 2013a Polymerization of non-complementary RNA: systematic symmetric nucleotide e xchanges mainly involving uracil produce mitochondrial RNA transcripts cod ing for cryptic overlapping genes. Biosystems 111\, 156-174.7. Seligmann H 2013b Systematic asymmetric nucleotide exchanges produce human mitochondr ial RNAs cryptically encoding for overlapping protein coding genes. J Theo r Biol 324\, 1-20.8. Seligmann H 2015 Codon expansion and systematic trans criptional deletions produce tetra-\, pentacoded mitochondrial peptides. J Theor Biol 387\, 154-165.9. Translation of mitochondrial swinger RNAs acc ording to tri-\, tetra- and pentacodons. Biosystems 140\, 38-48.10. Faure E\, Delaye L\, Tribolo S\, Levasseur A\, Seligmann H\, Barthélémy R-M 20 11 Probable presence of an ubiquitous cryptic mitochondrial gene on the an tisense strand of the cytochrome oxidase I gene. Biology Dir 6\, 56.https: //www.researchgate.net/profile/Herve_Seligmann CATEGORIES:Séminaire,Mathématiques-Évolution-Biologie END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Paris X-LIC-LOCATION:Europe/Paris BEGIN:DAYLIGHT DTSTART:20160327T030000 TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR