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UID:1173@i2m.univ-amu.fr
DTSTART;TZID=Europe/Paris:20160406T110000
DTEND;TZID=Europe/Paris:20160406T120000
DTSTAMP:20160322T100000Z
URL:https://www.i2m.univ-amu.fr/evenements/biased-gene-conversion-the-dark
 -side-of-recombination/
SUMMARY: (...): Biased Gene Conversion: the dark side of recombination
DESCRIPTION:: Recombination is typically thought as a symmetrical process r
 esulting in large-scale reciprocal genetic exchanges between homologous ch
 romosomes. Recombination events\, however\, are also accompanied by short-
 scale\, unidirectional exchanges in the neighborhood of the initiating dou
 ble-strand break: gene conversion. A large body of evidence suggests that 
 gene conversion is GC-biased in mammals. AT/GC heterozygotes produce a lar
 ger amount of GC- than AT-gametes\, thus conferring a population advantage
  to GC-alleles in high-recombining regions. This apparently unimportant fe
 ature of our molecular machinery has strong evolutionary consequences. Str
 ucturally\, GC-biased gene conversion (gBGC) explains the spatial distribu
 tion of GC-content in mammalian genomes - the so-called isochore structure
 . Functionally\, gBGC promotes the "undesired" segregation and fixation of
  deleterious AT->GC mutations\, thus increasing our genomic mutation load.
  I will present an analysis of the signatures of gBGC in the tree of life.
  Our results show that gBGC is probably a universal process\, present not 
 only in many eukaryotic taxa but also in bacteria.https://lbbe.univ-lyon1.
 fr/-Duret-Laurent-.html
CATEGORIES:Séminaire,Mathématiques-Évolution-Biologie
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DTSTART:20160327T030000
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