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UID:804@i2m.univ-amu.fr
DTSTART;TZID=Europe/Paris:20150624T110000
DTEND;TZID=Europe/Paris:20150624T120000
DTSTAMP:20241211T151027Z
URL:https://www.i2m.univ-amu.fr/evenements/catch-me-if-you-can-adaptation-
 from-standing-genetic-variation-to-a-moving-phenotypic-optimum/
SUMMARY: (...): Catch me if you can: Adaptation from standing genetic varia
 tion to a moving phenotypic optimum
DESCRIPTION:: Adaptation lies at the heart of Darwinian evolution. Natural 
 populations are constantly faced with environmental changes that force the
 m to either adapt or go extinct - a problem that is aggravated by human-in
 duced global change. Therefore\, increasing our understanding of the adapt
 ive process is important for both basic and applied research.\n-\nAccordin
 gly\, numerous studies have tried to provide a formal framework for the de
 scription of the adaptive process. Out of these\, two complementary modeli
 ng approaches have emerged: While so-called adaptive-walk models consider 
 adaptation from the successive fixation of de-novo mutations only\, quanti
 tative genetic models\, on the other hand\, assume that adaptation proceed
 s exclusively from pre-existing standing genetic variation. The latter app
 roach\, however\, has focused on short-term evolution of population means 
 and variances rather than on the statistical properties of adaptive substi
 tutions.\n-\nThus\, I will here address what has been described as "the mo
 st obvious theoretical limitation when describing the adaptive process" an
 d propose an analytical framework for the genetic basis of adaptation from
  standing genetic variation in terms of the effect-size distribution of in
 dividual alleles.\n-\nThis approach addresses one of the central questions
  in this context: From the multitude of standing genetic variants segregat
 ing in a population\, which are the ones that ultimately become fixed and 
 contribute to adaptation\, and how does their distribution differ from tha
 t of de-novo mutations?\n\n[http://www.mabs.at/matuszewski/index.html]&lt\
 ;emb657|center&gt\;
CATEGORIES:Séminaire,Mathématiques-Évolution-Biologie
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DTSTART:20150329T030000
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