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UID:7600@i2m.univ-amu.fr
DTSTART;TZID=Europe/Paris:20170321T103000
DTEND;TZID=Europe/Paris:20170321T123000
DTSTAMP:20241210T073217Z
URL:https://www.i2m.univ-amu.fr/evenements/dynamic-instability-of-microtub
 ules-and-effect-of-microtubule-targeting-agents-ayuna-barlukova/
SUMMARY:Ayuna Barlukova (I2M\, Aix-Marseille Université): Dynamic instabil
 ity of microtubules and effect of microtubule targeting agents
DESCRIPTION:Ayuna Barlukova: http://www.theses.fr/s110162\nModélisation d'
 instabilité dynamique des microtubules et l'effet des agents antimicrotub
 ules\n\nThe aim of this thesis is to design new mathematical models that a
 re able to appropriately describe dynamic instability of a population of m
 icrotubules (MTs) and effect of drugs on MT dynamics. MT dynamic instabili
 ty play an important role in the processes of mitosis and cell migration a
 nd\, thus\, in cancer progression. Dynamic instability is a complex proces
 s that involves different states of tubulin (polymerized or non-polymerize
 d\, GTP-tubulin or GDP-tubulin that correspond to two different energetic 
 states of tubulin dimers) that resulted from chemical processes (polymeriz
 ation\, depolymerization\, hydrolysis\, recycling\, nucleation) linking th
 ese different states of tubulin. Description of this complexity by mathema
 tical models enables one to test biological hypotheses concerning the impa
 ct of each process and action of drugs on microtubule dynamics. Recent obs
 ervations show that MT dynamics depends on aging of MT. One of the aims of
  the work is to test the hypothesis that MT aging results from the acceler
 ation of the GTP hydrolysis. We construct for that new models that couple 
 two multidimensional transport equations with two ordinary differential eq
 uations involving integral terms. We have calibrated our models on the bas
 is of experimental data\; tested biological hypothesis on mechanism of agi
 ng process\; performed a sensitivity analysis of the model with respect to
  parameters describing chemical processes\; and tested hypotheses concerni
 ng actions of drugs.\n\nMembres du jury :\n- Assia BENABDALLAH\, PU\, Aix-
 Marseille Universite\, Examinateur\n- Francois DEVRED\, MCF - HDR\, Aix-Ma
 rseille Universite\, Examinateur\n- Stéphane HONORÉ\, PU-PH\, Aix-Marsei
 lle Universite\, Codirecteur\n- Florence HUBERT\, PU\, Aix-Marseille Unive
 rsite\, Directrice\n- Clair POIGNARD\, CR1 - HDR\, INRIA Bordeaux Sud Oues
 t\, Rapporteur\n- Christian POÜS\, PU-PH\, Châtenay-Malabry\, Rapporteur
 \n- Magali RIBOT\, PU\, Université d'Orleans\, Examinateur\n- Angélique 
 STEPHANOU\, CR CNRS - HDR\, TIMC Grenoble\, Examinateur\n\nhttps://www.res
 earchgate.net/profile/Barlukova_Ayuna\n\nLien : theses.fr
ATTACH;FMTTYPE=image/jpeg:https://www.i2m.univ-amu.fr/wp-content/uploads/2
 020/01/Ayuna_Barlukova.jpg
CATEGORIES:Soutenance de thèse,Analyse Appliquée
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