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UID:8667@i2m.univ-amu.fr
DTSTART;TZID=Europe/Paris:20250507T090000
DTEND;TZID=Europe/Paris:20250507T110000
DTSTAMP:20250429T132236Z
URL:https://www.i2m.univ-amu.fr/evenements/from-logical-modelling-to-trans
 criptomic-data-analysis-a-systems-biology-perspective-2/
SUMMARY:Nadine Ben Boina (I2M): From logical modelling to transcriptomic da
 ta analysis – A systems biology perspective
DESCRIPTION:Nadine Ben Boina: Abstract:\nBiological systems are inherently 
 complex. They are composed of numerous elements whose interactions give ri
 se to emergent properties. The study of these systems often relies on holi
 stic approaches that account for both the entire system and the interactio
 ns among its various components. In particular\, mathematical modelling is
  a powerful tool for simulating and analysing the behaviour of biological 
 systems. Among the existing mathematical models\, logical models (both Boo
 lean and multivalued) distinguish themselves by their minimal reliance on 
 quantitative data.\n\nMy thesis focuses on studying biological systems usi
 ng logical models. After introducing systems biology and logical modelling
 \, I present my main contribution: a method for refining Boolean models\, 
 termed “Multivalued Refinements of Boolean Models” (MRBM). Boolean mod
 els use binary variables to represent the activity of biological component
 s\, but this simplification can lead to an incomplete representation of a 
 system's dynamics. Multivalued models can overcome this limitation by allo
 wing components to adopt more than two activity levels. However\, determin
 ing which components should be modelled as multivalued remains a challenge
 . The MRBM method addresses this challenge by leveraging a new updating st
 rategy\, called “partial most permissive” updating\, which is based on
  the classical “most permissive” scheme.\n\nThis thesis also includes 
 a collaborative study on RNA sequencing data from mice affected by Hutchin
 son-Gilford Progeria syndrome. This study illustrates a different approach
  to studying biological systems — other than logical modelling.\n\n\nThe
  Jury:\nMme Laurence Calzone\, Institut Curie — Rapportrice\nMme Madalen
 a Chaves\, INRIA — Rapportrice\nM. Paul Ruet\, CNRS — Examinateur\nM. 
 Elias Ventre\, INRIA — Examinateur\nM. Denis Thieffry\, IBENS — Examin
 ateur\nM. Jacques Van Helden\, AMU — Président du jury\nMme Anaïs Baud
 ot\, MMG — Directrice de thèse\nMme Élisabeth Rémy\, I2M — Directri
 ce de thèse
CATEGORIES:Soutenance de thèse,MABioS
LOCATION:Luminy - Auditorium de l'Hexagone\, 172 avenue de Luminy\, Marseil
 le\, 13009\, France
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=172 avenue de Luminy\, Mars
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 'Hexagone:geo:0,0
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