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UID:1613@i2m.univ-amu.fr
DTSTART;TZID=Europe/Paris:20170306T110000
DTEND;TZID=Europe/Paris:20170306T120000
DTSTAMP:20170219T100000Z
URL:https://www.i2m.univ-amu.fr/evenements/genomic-sources-of-morphologica
 l-innovation-the-evolution-of-wing-pigmentation-in-drosophila/
SUMMARY: (...): Genomic sources of morphological innovation: the evolution 
 of wing pigmentation in Drosophila.
DESCRIPTION:: The past 20 years of comparative developmental genetic studie
 s have shown that the formation of morphological traits is under the contr
 ol of genetic regulatory networks made of evolutionary conserved component
 s. However it remains unclear how alterations of those networks lead to mo
 rphological innovations.The evolution of a pigmentation spot located on th
 e wing of some Drosophila males is a great model to tackle this question\,
  notably because it is genetically tractable and has evolved several times
  in the melanogaster group. Using a comparative and integrative approach w
 e are mapping on the drosophila tree the genomic changes that caused chang
 es in the genetic regulatory network of wing pigmentation. During the pres
 entation we will introduce our methodology as well computational and stati
 stical challenges. In order to identify genes whose changes in spatio-temp
 oral expression underlie the evolution of wing pigmentation\, we are compa
 ring gene expression using RNA-seq throughout wing pupal development in 3 
 different species and between sexes. In order to understand the genetic de
 terminism of these gene expression changes we are investigating transcript
 ional regulatory changes between conditions. To this end we have opted for
  a dual strategy: we have employed functional genomics methods such as ChI
 P-seq and ATAC-seq to identify regulatory sequences and we are comparing t
 ranscription factor binding sites composition between species. We are test
 ing the involvement of a dozen candidates in the evolution of wing spot fo
 rmation by using a combination of CRISPR/Cas9-targeted mutagenesis\, RNAi 
 knockdown and overexpression assays in pupae of the spotted species D. bia
 rmipes.| Webpage | Webpage ||  |  |
CATEGORIES:Séminaire,Mathématiques-Évolution-Biologie
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