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TZID:Europe/Paris
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BEGIN:VEVENT
UID:7821@i2m.univ-amu.fr
DTSTART;TZID=Europe/Paris:20160509T140000
DTEND;TZID=Europe/Paris:20160509T160000
DTSTAMP:20241120T204843Z
URL:https://www.i2m.univ-amu.fr/evenements/negative-local-feedbacks-in-boo
 lean-networks-paul-ruet/
SUMMARY:Paul Ruet (IRIF\, Université Paris Diderot): Negative local feedba
 cks in Boolean networks - Paul Ruet
DESCRIPTION:Paul Ruet: \nBoolean networks represent the interaction of fini
 tely many variables which may take two values\, 0 and 1. They have been ex
 tensively used as models of various biological networks\, notably genetic 
 regulatory networks since the early works of S. Kauffman and R. Thomas. In
  this context\, a variable models the (discretized) expression level of a 
 gene\, and certain dynamical properties of the network have a natural biol
 ogical interpretation: the existence of several fixed points (or more gene
 rally attractors) corresponds to cellular differentiation\, and sustained 
 oscillations (cyclic attractors) correspond to a form of homeostasis. In t
 his talk\, I will give an overview of recent results relating these dynami
 cal properties to the structure of the networks\, in terms of (positive or
  negative\, local or global) cycles. In particular\, we shall see that\, w
 hile the existence of several fixed points is well-known to imply the exis
 tence of a local positive cycle\, sustained oscillations do not imply the 
 existence of a local negative cycle.\n\n
ATTACH;FMTTYPE=image/jpeg:https://www.i2m.univ-amu.fr/wp-content/uploads/2
 020/01/Paul_Ruet.jpg
CATEGORIES:Séminaire,MABioS
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DTSTART:20160327T030000
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