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TZID:Europe/Paris
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UID:1147@i2m.univ-amu.fr
DTSTART;TZID=Europe/Paris:20160323T110000
DTEND;TZID=Europe/Paris:20160323T120000
DTSTAMP:20160308T100000Z
URL:https://www.i2m.univ-amu.fr/evenements/next-generation-sequencing-stre
 ngths-and-weaknesses-of-the-ongoing-sequencing-revolution-to-assess-immune
 -variability/
SUMMARY: (...): ‘Next Generation Sequencing’: Strengths and Weaknesses 
 of the Ongoing Sequencing Revolution to Assess Immune Variability
DESCRIPTION:: Over the past 10 years\, the development of Next Generation S
 equencing approaches has led to a 4-log drop in sequencing costs. This dev
 elopment has made it possible to tackle projects that were once considered
  impossible due to the high costs involved. One such project is for exampl
 e the 1\,000 Genomes Project that is aimed at defining human genetic diver
 sity Worldwide. I will develop in this presentation how the combination of
  the characteristics of the sequences generated in these projects and the 
 methodological approaches used to analyze these sequences often leads to t
 he mischaracterization of the most variable immune regions. An example of 
 a novel gene characterized in the laboratory will be presented to illustra
 te both the challenges and the importance of these analyses. Finally\, I w
 ill discuss how these analyses can be integrated to generate more realisti
 c and accurate evolutionary studies\, in particular studies of convergent 
 or parallel evolution.    
CATEGORIES:Séminaire,Mathématiques-Évolution-Biologie
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DTSTART:20151025T020000
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