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UID:7616@i2m.univ-amu.fr
DTSTART;TZID=Europe/Paris:20170306T140000
DTEND;TZID=Europe/Paris:20170306T150000
DTSTAMP:20241120T204427Z
URL:https://www.i2m.univ-amu.fr/evenements/pediatric-cancer-subtype-charac
 terization-through-network-and-multi-omics-data-analysis-loredana-martigne
 tti/
SUMMARY:Loredana Martignetti (Institut Curie\, Paris): Pediatric cancer sub
 type characterization through network and multi-omics data analysis -  Lor
 edana Martignetti
DESCRIPTION:Loredana Martignetti: Cancers are typically classified dependin
 g on their tissue of origin. However\, recent largescale genomic experimen
 ts are providing more detailed molecular characterizations of tumors\, bri
 nging the possibility of a more accurate stratification of tumor subtypes.
  To date\, mainly owing to the maturity and availability of high throughpu
 t DNA- and RNA- based techniques\, molecular classifications of complex di
 seases primarily focus on genomics and transcriptomics. Protein-level meas
 urements are underutilized due to technical hurdles. Here\, we present an 
 integrative approach including deep proteomic measurements and transcripto
 mic profiles of pediatric brain tumors to decipher signaling pathways and 
 molecular mechanisms underlying different tumor subtypes. This analysis yi
 elds a number of insights about quantitative concordance between mRNA expr
 ession and protein levels in tumor profiles. We applied a pathwaybased app
 roach\, called ROMA for Representation and quantification Of Module Activi
 ty [1]\, to capture biological information that is otherwise undetectable 
 by focusing on individual genes. Our results uncover deregulations in some
  signaling pathways specific to poor outcome subgroups\, possibly underlyi
 ng mechanisms linked to bad prognosis.\n\n[1] Martignetti L\, Calzone L\, 
 Bonnet E\, Barillot E\, Zinovyev A. ROMA: Representation and Quantificatio
 n of Module Activity from Target Expression Data. Front Genet. 2016 Feb 19
 \;7:18
ATTACH;FMTTYPE=image/jpeg:https://www.i2m.univ-amu.fr/wp-content/uploads/2
 017/03/Loredana_Martignetti.jpg
CATEGORIES:Séminaire,MABioS
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DTSTART:20161030T020000
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