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TZID:Europe/Paris
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BEGIN:VEVENT
UID:7058@i2m.univ-amu.fr
DTSTART;TZID=Europe/Paris:20190429T110000
DTEND;TZID=Europe/Paris:20190429T120000
DTSTAMP:20241120T203408Z
URL:https://www.i2m.univ-amu.fr/evenements/predicting-protein-annotations-
 using-the-expected-network-interaction-between-related-diseases-or-cellula
 r-processes-francisco-rodrigues-pinto/
SUMMARY:Francisco Rodrigues Pinto (Universidade de Lisboa): Predicting prot
 ein annotations using the expected network interaction between related dis
 eases or cellular processes - Francisco Pinto
DESCRIPTION:Francisco Rodrigues Pinto: Genes or proteins involved in the sa
 me cellular process or disease tend to cluster together within biological 
 networks. This fact is used by numerous algorithms to predict new protein 
 functions or disease associations.\n-\nWe hypothesize that knowing that tw
 o (or more) cellular processes or diseases are functionally related may im
 prove our ability to predict new proteins associated with both processes o
 r diseases. I will present two methods that are being developed in my rese
 arch group based in the previous hypothesis.\n-\nThe first is a specific v
 ersion of betweenness centrality\, called S2B\, that predicts the simultan
 eous association of a protein with two related diseases. For each candidat
 e protein\, this method measures the frequency with which that protein is 
 part of shortest paths linking proteins associated with one disease to pro
 teins associated with the other disease.\n-\nThe second method aims to exp
 and the list of proteins associated with a seed cellular process. It first
  identifies other cellular processes that specifically interact with seed 
 proteins of the queried cellular process. Seed direct neighbors are then c
 ompared with the seeds by their ability to bridge the query process with t
 he specific neighbor processes. This comparison allows the classification 
 of seed direct neighbors as being involved (or not) in the seed process.\n
 http://ciencias.ulisboa.pt/pt/perfil/frpinto
ATTACH;FMTTYPE=image/jpeg:https://www.i2m.univ-amu.fr/wp-content/uploads/2
 020/01/Francisco_Pinto.jpg
CATEGORIES:Séminaire,MABioS
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DTSTART:20190331T030000
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