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UID:2473@i2m.univ-amu.fr
DTSTART;TZID=Europe/Paris:20180925T110000
DTEND;TZID=Europe/Paris:20180925T120000
DTSTAMP:20180910T090000Z
URL:https://www.i2m.univ-amu.fr/evenements/singular-manifolds-of-proteomic
 -drivers-controlling-the-dynamic-of-inflammatory-bowel-disease-status/
SUMMARY: (...): Singular manifolds of proteomic drivers controlling the dyn
 amic of inflammatory bowel disease status
DESCRIPTION:: The conditions of an immune disease can often be represented 
 by interaction graphs\, but how those complex graphs are susceptible to in
 terventions is still of utmost importance in areas such as reprogramming t
 herapeutics. In this sense\, module identification is an essential step to
 wards understanding the whole graph architecture. The consideration of a g
 eneral class of node dissimilarity measures related to the notion of topol
 ogical overlap enables detecting ``driver'' genes with high specificity in
  these modules. These module regulators can affect other nodes\, potential
 ly causing the entire system to change behaviour or fail. We provide a geo
 metric framework based on singular manifolds explaining such situations in
  inflammatory bowel disease (IBD). IBD are important chronic disorders of 
 the gastrointestinal tract which incidence is dramatically increasing worl
 dwide. Our approach models those scenarios by reinterpreting the nonlinear
  dynamics intrinsic to real systems captured as compensatory responses to 
 perturbations of a graph on its manifold of definition. Thus\, we are able
  to reconfiguring the immune system to a desired target state. We illustra
 te the effectiveness of the strategy through the identification of potenti
 al drivers controlling the dynamic of IBD gene co-expression networks resu
 lting from two high throughput proteome screenings.http://www.math.univ-pa
 ris13.fr/laga/membres/Morilla
CATEGORIES:Séminaire,Analyse Appliquée
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DTSTART:20180325T030000
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