Alternative transcriptions and translations expand the human mitogenomic proteome

Date(s) : 11/05/2016   iCal
11 h 00 min - 12 h 00 min

Nucleotide sequences, such as rRNA genes, are multi-tasked, beyond ‘known’ function, i.e. coding for the protein ribin [1].
Regular protein coding genes might actually code for several widely different proteins due to:
(a) translational activity by stop-suppressor tRNAs [2,3](b) tRNAs with expanded codons [4,5](c) Systematic transcriptional transformations alter coding and other properties of RNAs, such as systematic deletions after each trinucleotide,
or systematic nucleotide exchanges (e.g. A<->G) over complete genes [6,7].
Human mitochondrial RNAs sequenced by classical and next generation methods match various transformations.
Peptides matching specifically detected transformed RNAs occur in human mass spectrometry mitoproteomic data [8,9], have also been detected by monoclonal antibodies [10].
Alternative transcriptions and translations explain trashed -omic data, increasing considerably coding potential.

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