Diversity generation in immune receptor repertoires.

Date(s) : 23/11/2016   iCal
11 h 00 min - 12 h 00 min

Recognition of pathogens relies on the diversity of immune receptor proteins. Recent experiments that sequence the entire immune cell repertoires provide a new opportunity for quantitative insight into naturally occurring diversity and how it is generated. The generation process is implemented via a series of stochastic molecular events involving gene choices and random nucleotide insertions between, and deletions from, genes. I will describe how we can quantify the origins of diversity in these sequence and characterize selection in the somatic evolutionary process that leads to the observed receptor diversity.



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