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standing_genetic_variation [2013/06/13 10:50] – mkoppstanding_genetic_variation [2019/03/21 09:21] (current) – external edit 127.0.0.1
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 Possible analytical approaches: Possible analytical approaches:
-* Hermisson/Pennings with moving optimum (selection gradient increases linearly); use results from Uecker and Hermisson 2011? +  * Hermisson/Pennings with moving optimum (selection gradient increases linearly); use results from Uecker and Hermisson 2011? 
-* Hermisson/Pennings for quantitative trait (functional relationship between selection coefficients before and after environmental change; ask which mutation from sgv is most likely to fix first) +  * Hermisson/Pennings for quantitative trait (functional relationship between selection coefficients before and after environmental change; ask which mutation from sgv is most likely to fix first) 
-* use bi-allelic infinite sites model without linkage as a simple extension of one-locus case +  * use bi-allelic infinite sites model without linkage as a simple extension of one-locus case 
-* Concentrate on HC-regime (relatively low mutation rate, distribution of new mutations independent of parent allele; predominant wild-type allele)+  * Concentrate on HC-regime (relatively low mutation rate, distribution of new mutations independent of parent allele; predominant wild-type allele) 
 +  * Potentially useful papers: Keightly and Hill 1988, Foley 1982)
  
  
 Simulations: Simulations:
-* Study simple cases (one-locus; two-allele infinite sites) +  * Study simple cases (one-locus; two-allele infinite sites) 
-* make comparisons: sudden vs. gradual change; new mutations vs. sgv+  * make comparisons: sudden vs. gradual change; new mutations vs. sgv