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Aix-Marseille Université
Institut de Mathématiques de Marseille (I2M) - UMR 7373
Site Saint-Charles : 3 place Victor Hugo, Case 19, 13331 Marseille Cedex 3
Site Luminy : Campus de Luminy - Case 907 - 13288 Marseille Cedex 9

Séminaire

Singular manifolds of proteomic drivers controlling the dynamic of inflammatory bowel disease status




Date(s) : 25/09/2018   iCal
11h00 - 12h00

The conditions of an immune disease can often be represented by interaction graphs, but how those complex graphs are susceptible to interventions is still of utmost importance in areas such as reprogramming therapeutics. In this sense, module identification is an essential step towards understanding the whole graph architecture. The consideration of a general class of node dissimilarity measures related to the notion of topological overlap enables detecting « driver » genes with high specificity in these modules. These module regulators can affect other nodes, potentially causing the entire system to change behaviour or fail. We provide a geometric framework based on singular manifolds explaining such situations in inflammatory bowel disease (IBD). IBD are important chronic disorders of the gastrointestinal tract which incidence is dramatically increasing worldwide. Our approach models those scenarios by reinterpreting the nonlinear dynamics intrinsic to real systems captured as compensatory responses to perturbations of a graph on its manifold of definition. Thus, we are able to reconfiguring the immune system to a desired target state. We illustrate the effectiveness of the strategy through the identification of potential drivers controlling the dynamic of IBD gene co-expression networks resulting from two high throughput proteome screenings.

http://www.math.univ-paris13.fr/laga/membres/Morilla

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