Dynamic cell population modeling with UpPMaBoSS – Laurence Calzone

Laurence Calzone
Institut Curie, Paris
https://www.researchgate.net/profile/Laurence_Calzone

Date(s) : 11/07/2019   iCal
11 h 00 min - 12 h 00 min

UpPMaBoSS is a new framework for dynamical modeling of circulating cell populations, based on qualitative models of the intra-cellular mecanisms. It relies on the pre-existing tool MaBoSS, which estimates a distribution of probabilities of individual cellular states. Here, we propose to interpret this distribution of probabilities as a mirror of the composition of an heterogeneous cell population.
UpPMaBoSS enables this interpretation by accounting for inter-cellular communication, cell division and cell death.

 

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