‘Next Generation Sequencing’: Strengths and Weaknesses of the Ongoing Sequencing Revolution to Assess Immune Variability

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Date(s) - 23/03/2016
11 h 00 min - 12 h 00 min


Over the past 10 years, the development of Next Generation Sequencing approaches has led to a 4-log drop in sequencing costs. This development has made it possible to tackle projects that were once considered impossible due to the high costs involved. One such project is for example the 1,000 Genomes Project that is aimed at defining human genetic diversity Worldwide. I will develop in this presentation how the combination of the characteristics of the sequences generated in these projects and the methodological approaches used to analyze these sequences often leads to the mischaracterization of the most variable immune regions. An example of a novel gene characterized in the laboratory will be presented to illustrate both the challenges and the importance of these analyses. Finally, I will discuss how these analyses can be integrated to generate more realistic and accurate evolutionary studies, in particular studies of convergent or parallel evolution.

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